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CALEDO
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The Center
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CALEDO Staff
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Managing Director
PD Dr. Ing. Christoph Brandenbusch
in pharmaceutical biotechnology [1]. The low solubilities achieved in state of the art formulations commonly only allows their administration via intravenous injection [1]. An increase in protein concentration [...] antibodies and proteins is an emerging field in biotechnology due to their high specificity with antigens [1]. However, most of the proteins have a poor solubility in water and therefore their application is mostly [...] suitable additives shall be identified that increase the protein concentration up to 150 to 200 mg mL-1 to enable subcutaneous administration of these formulations with higher patient compliance. Further …